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Tuesday, July 21, 2020 | History

5 edition of Natural and Induced Cell-mediated Cytotoxicity (Perspectives in immunology) found in the catalog.

Natural and Induced Cell-mediated Cytotoxicity (Perspectives in immunology)

by G. Reithmuller

  • 208 Want to read
  • 24 Currently reading

Published by Academic Press Inc.,U.S. .
Written in English


The Physical Object
Number of Pages255
ID Numbers
Open LibraryOL7328687M
ISBN 100125846509
ISBN 109780125846509

Get this from a library! Natural and induced cell-mediated cytotoxicity: effector and regulatory mechanisms: proceedings of the Erwin Riesch Symposium, organized on the occasion of the fifth centennial of the University of Tübingen at Weitenburg bei Tübingen, Germany, October , [Gert Riethmüller; Peter Wernet; Gustavo Cudkowicz;] -- Natural and Induced Cell-Mediated Cytotoxicity. Unique cell profiles, in respect to the extent of sensitivity to NK cell-mediated cytotoxicity, cell growth, and viability, were observed when OSCSCs, MP2, and SCAPs were treated with either supernatant or fixed IL-2 + anti-CD16mAb + sAJ2-treated NK cells (Figures (Figures2 2 and and3; 3; Figures S2 and S5 in Supplementary Material.

Antibody-dependent cellular cytotoxicity (ADCC) and complement fixation both appear to play a role in mediating antitumor effects of monoclonal antibodies (mAbs), including rituximab. We evaluated the relationship between rituximab-induced complement fixation, natural killer (NK)-cell activation, and NK cell-mediated ADCC.   We have previously shown that long-term (day) culture of PBMCs with IPP+IL-2 results in the induction of NK cell–mediated cytotoxicity against tumors that are normally resistant to NK-cell killing. 4 We also observed that IPP did not stimulate NK cells directly and γδ T lymphocytes were critical for IPP-induced NK-cell cytotoxicity.

Antibody-dependent cellular cytotoxicity (ADCC), also called antibody-dependent cell-mediated cytotoxicity, is an immune mechanism through which Fc receptor-bearing effector cells can recognize. ligand, activation-induced C-type lectin (AICL),27 AICL is upregulated on activated monocytes and NK cells, and NKp80–AICL interaction promotes NK cell-mediated control of monocytes and autologous NK cells Natural killer cells also express the members of the sig-nalling lymphocytic activation molecule (SLAM) family of receptors.


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Natural and Induced Cell-mediated Cytotoxicity (Perspectives in immunology) by G. Reithmuller Download PDF EPUB FB2

The symposium provided a forum for reviewing the progress that has been made in understanding the effector and regulatory mechanisms underlying natural and induced cell-mediated cytotoxicity. Topics covered range from the immunobiology of natural killer cells to the role of macrophages as regulator, accessory, and effector cells in cytotoxicity.

Purchase Natural and Induced Cell-Mediated Cytotoxicity - 1st Edition. Print Book & E-Book. ISBNBook Edition: 1. Mattes MJ, Sharrow SO, Herberman RB, Holden HT. Identification and separation of Thy-1 positive mouse spleen cells active in natural cytotoxicity and antibody-dependent cell-mediated cytotoxicity.

J Immunol. Dec; (6)–Cited by: The book Cytotoxicity is aimed to be an essential reading to all medical students, biologists, biochemists and professionals involved in the field of toxicology.

This book is a useful and ideal guide for novice researchers interested in learning research methods to study cytotoxic bioactive compounds. Natural and Induced Cell-Mediated.

Purchase Natural Cell-Mediated Immunity Against Tumors - 1st Edition. Print Book & E-Book. ISBNBook Edition: 1. This chapter highlights the manipulations of natural cytotoxicity in tumor patients via bacillus calmette-guerin (BCG). Local BCG stimulation induces a systemic short-lasting cytotoxicity response that can be easily monitored in the peripheral blood by use of the 3 H-proline release test.

This reaction seems to depend on the number of BCG organisms applied. Natural cytotoxicity of human blood lymphocytes against target cells from the myeloid cell line K was analyzed in a 51 Cr release assay.

The effector cells involved were characterized and some data favoring the role of immunoglobulin in the induction of this cytotoxicity are presented. Possible role of extracellular ATP in cell-cell interactions leading to CTL-mediated cytotoxicity. in: Sitkovsky M. Hendart P. Cytotoxic Cells.

Birkhauser, Boston   In this study, we examined the susceptibility of senescent human breast cancer cells to immune cell‐mediated cytotoxicity. Doxorubicin (DXR) treatment induced senescence in 2 human breast cancer cell lines, MDA‐MB‐ and BT‐, with the induction of γH2AX expression and increased expression of p21 or p Hypovitaminosis D is associated with an adverse prognosis in colon cancer patients, possibly due to the effects of the vitamin on the immune system.

Antibody-dependent cell-mediated cytotoxicity (ADCC) significantly contributes to the anti-tumor effects of monoclonal antibodies, including cetuximab, an epidermal growth factor receptor (EGFR)-targeted monoclonal antibody that is frequently. A total of 50 lung cancer (CA) patients and 20 normal persons as controls were included in our study.

We obtained lymphocytes from heparinized blood by Ficoll-Hypaque gradient method, and after the macrophages were removed, they were incubated with 51 Cr-labelled K cells at concentrations of, for four hours.

We calculated the cytotoxicity activity and lytic. Antibody-dependent cellular cytotoxicity (ADCC), also referred to as antibody-dependent cell-mediated cytotoxicity, is a mechanism of cell-mediated immune defense whereby an effector cell of the immune system actively lyses a target cell, whose membrane-surface antigens have been bound by specific antibodies.

It is one of the mechanisms through which antibodies, as part of the humoral immune. The second type of cell-mediated responses we studied for their susceptibility to CyA was the natural cytotoxic reactivity against tumor cells such as natural killer (NK) activity, whose effector cell is thought to be an immature T lymphocyte (Herberman & Holden, ), and natural macrophage cytotoxicity (Keller, ; Tagliabue, Mantovani.

Then we further measured antigen-specific T-cell-mediated cytotoxicity in autophagy-deficient MDA-MB cells. Peptide – from naturally processed p53. Baysal, H., De Pauw, I., Zaryouh, H.

et al. Cetuximab-induced natural killer cell cytotoxicity in head and neck squamous cell carcinoma cell lines: investigation of. A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity. Proc. Natl Acad. Sci. – ().

Discover the best Cytotoxicity books and audiobooks. Learn from Cytotoxicity experts like Frontiers and SAI Global - APAC. Read Cytotoxicity books like tmp4F8D and As Laminar Flow Cytotoxic Drug Safety Cabinets - Installation and Use with a free trial.

Cite this article. Kägi, D., Ledermann, B., Bürki, K. et al. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient. Anti-CD monoclonal antibody enhances trastuzumab-induced, natural killer cell-mediated cytotoxicity against pancreatic cancer cell lines with low human epidermal growth factor-like receptor 2 expression.

Antigen-dependent cell-mediated cytotoxicity (ADCC) is the initial mechanism of action of Tmab [15, 16]. NK cells display natural cell-mediated cytotoxicity (CMC) against cancer cells through the detection of stress ligands (also known as “induced self”), mediated by NKG2D and other activating receptors, or through recognition of “missing self” when tumor cells have low surface expression of MHC class I.

Le Drean, E. et al. Inhibition of antigen-induced T cell response and antibody-induced NK cell cytotoxicity by NKG2A: association of NKG2A with SHP-1 and SHP-2 protein-tyrosine phosphatases. Eur. J.Di Biase et al.

show that combining a fasting-mimicking diet with chemotherapy increases the levels of bone marrow common lymphoid progenitor cells and cytotoxic CD8+ tumor-infiltrating lymphocytes, delaying tumor progression. In breast tumors, this effect is partially mediated by downregulating HOH9 cells expressed more cell surface ULBP2 than Jurkat cells, and therefore a higher concentration of ULBP2 was detected in H9 supernatants.

Consistent with apoptotic compound treatments, NK cell-mediated cytotoxicity also induced shedding of ULBP2 from Jurkat (Fig.

4C) and H9 cells (Fig. 4D) into cell culture supernatants.